Arthritis & Rheumatism, Volume 60,
October 2009 Abstract Supplement
The 2009 ACR/ARHP Annual Scientific Meeting
Philadelphia October 16-21, 2009.
Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody Profile in Patients with Morphea
Kellet, Cristián Vera, Dutz, Jan P.
Systemic autoimmune disease is more common in patients with morphea. Rheumatoid factor (RF) has been reported in a subset of patients with morphea, but the significance of this remains unclear. Anti-cyclic citrullinated peptide antibody (anti-CCP) is a sensitive and specific marker for the diagnosis of rheumatoid arthritis that has not been examined in morphea.The aim of this study was to determine the presence of RF and anti-CCP antibodies in patients with morphea, who attended a Dermatology Connective Tissue Disease Clinic and to assess any association between the presence of RF and anti-CCP, disease activity and clinical manifestations.
This was a retrospective study. We reviewed all the charts of patients with a diagnosis of morphea assessed between January 2006 and December 2008.
54/72 patients with morphea had at least one RF assessment (43 women and 11 men, mean age 44.3 years). RF was negative (< 10 kU/L) in 48 % (26/54) of patients, and it was positive either at low (>10 kU/L and <30 kU/L) or high (>30 kU/L) titers in 52% (28/54). There was a trend to generalised versus linear morphea in patients with a high positive RF compared to those with a negative RF (9/12 versus 14/26). There was a trend to active disease in those patients with a high positive RF compared to those with a negative RF (12/12 active versus 21/26). In 2 patients, RF reverted from positive to negative when their disease became clinically inactive. Only 7/28 patients with a positive RF had co-morbid diseases previously associated with RF: Hepatitis B or C (3), autoimmune liver disease (1), SLE (1), SLE/MCTD (2). All patients tested for anti-CCP (including 9/12 with high positive RF and 7/16 with low titre RF) were negative.
RF can be positive in morphea, and it may be used as a marker of disease activity. Anti-CCP was not positive in any of our patients with morphea. RF seropositivity is not a marker of RA in patients with morphea and likely connotes B-cell dysregulation in these patients.
To cite this abstract, please use the following information:
Kellet, Cristián Vera, Dutz, Jan P.; Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody Profile in Patients with Morphea [abstract]. Arthritis Rheum 2009;60 Suppl 10 :796