Arthritis & Rheumatism, Volume 60,
October 2009 Abstract Supplement

The 2009 ACR/ARHP Annual Scientific Meeting
Philadelphia October 16-21, 2009.

The Georgia Lupus Registry: A Population-Based Estimate of the Incidence and Prevalence of Childhood-Onset SLE

Lim1,  S. Sam, Bayakly2,  Rana, Helmick3,  C.G., Gordon4,  Caroline, Easley1,  Kirk, Shenvi1,  Neeta, Vogler1,  Larry B.

Emory University, Atlanta, GA
Georgia Department of Human Resources, Atlanta, GA
Centers for Disease Control and Prevention, Atlanta, GA
University of Birmingham, Birmingham, United Kingdom

Introduction and Purpose:

There are no population-based studies estimating the prevalence and incidence rates of childhood-onset SLE in the US. Our aim was to describe these rates in Atlanta from 2002 through 2004.

Methods:

The Georgia Lupus Registry is a population-based registry designed to estimate the incidence and prevalence of SLE in Atlanta, Georgia (Fulton and DeKalb counties). Case-finding utilizes multiple sources. Trained abstractors document nearly 250 demographic and clinical elements from medical records of potential SLE patients. All sources with potential SLE patients (<20 years old) have been abstracted. 31 incident and 51 prevalent patients met the case definition for this study: having either >=4 ACR criteria or 3 ACR criteria and diagnosis of SLE by a rheumatologist.

Results:

Table 1. Annual average standardized incidence rates in Atlanta (2002–2004)

  Age GroupPopulation (0–19 years old)CasesaAge Standardized IRb (95% CI)cCrude IR (95% CI)c
Overall  1,293,062312.5 (1.6–3.4) 
BlackTotal 745,397273.6 (2.3–5) 
 Male 376,03961.6 (0.3–2.9) 
  0–9 0 0 (0–2)
  10–14 2 2 (0.2–7.1)
  15–19 4 4.4 (1.2–11.4)
 Female 369,358215.7 (3.2–8.1) 
  0–9 1 0.6 (0–3.1)
  10–14 6 6.1 (2.2–13.2)
  15–19 14 15.3 (8.4–25.7)
WhiteTotal 492,77720.5 (0–1.1) 
 Male 253,07300 (0–0) 
 Female 237,7042d0.9 (0–2.2) 
  0–9 0 0 (0–2.8)
  10–14 2 3.6 (0.4–13.1)
  15–19 0 0 (0–7.2)
a remainder of cases were Asians with CI's too wide and estimates too unreliable to report
b incidence rates (IR) and prevalence rates (PR) per 100,000; calculated by direct method using US census data (2000)
c calculated by exact method
d both of Hispanic ethnicity

Table 2. Standardized prevalence rates in Atlanta (2002)

  Age GroupPopulation (0–19 years old)CasesaAge Standardized PRb (95% CI)cCrude PR (95% CI)c
Overall  424,1285112.6 (9.1–16.1) 
BlackTotal 249,2764518.4 (13–23.8) 
 Male 125,78897.3 (2.5–12.1) 
  0–9 0 0 (0–5.9)
  10–14 4 11.9 (3.2–30.5)
  15–19 5 17 (5.5–39.6)
 Female 123,4883629.5 (19.9–39.2) 
  0–9 1 1.6 (0–9.1)
  10–14 13 39.6 (21.1–67.8)
  15–19 22 74.1 (46.4–112.1)
WhiteTotal 157,37810.7 (0–2.1) 
 Male 81,59100 (0–0) 
 Female 75,78811.5 (0–4.5) 
  0–9 0 0 (0–8.9)
  10–14 0 0 (0–21)
  15–19 1 6 (0.2–33.6)
a remainder of cases were Asians with CI's too wide and estimates too unreliable to report
b incidence rates (IR) and prevalence rates (PR) per 100,000; calculated by direct method using US census data (2000)
c calculated by exact method

To cite this abstract, please use the following information:
Lim, S. Sam, Bayakly, Rana, Helmick, C.G., Gordon, Caroline, Easley, Kirk, Shenvi, Neeta, et al; The Georgia Lupus Registry: A Population-Based Estimate of the Incidence and Prevalence of Childhood-Onset SLE [abstract]. Arthritis Rheum 2009;60 Suppl 10 :714
DOI: 10.1002/art.25794

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