Arthritis & Rheumatism, Volume 60,
October 2009 Abstract Supplement

The 2009 ACR/ARHP Annual Scientific Meeting
Philadelphia October 16-21, 2009.

Association Between Bone Mineral Density and High-Sensitivity CRP in a Large Population-Based Sample

de Pablo,  Paola, Buckley,  Christopher


Several studies suggest that bone mineral density (BMD) is reduced in chronic inflammatory diseases. Higher serum levels of hs-CRP have been associated with lower BMD in women and older adults. However, whether this association holds in a representative sample of the general population is unclear. The purpose was to examine the relationship between BMD and hsCRP in a large representative US population-based sample from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2004.


We selected subjects over age 20 with BMD (total and subregions) measured by dual-energy x-ray absorptiometry scans from NHANES 1999–2004. The association between CRP concentrations and BMD was evaluated using multivariable linear regression models adjusting for potential confounders. Sensitivity analyses included further adjustment for vitamin D levels, participants taking prescriptions medications, or comorbid diseases, such as arthritis, COPD, CVD, CHF, and stroke.


The study sample included 11,065 participants with a mean age of 50 years (range 20–85). Of those, 53% were Caucasians, 22% were Mexican-American, 18% were African-American, and 7% other races, and 52% were women. Men had higher BMD and lower hs-CRP concentrations than women. BMD (total, subtotal, extremities, ribs, and trunk) was inversely associated with CRP quintiles both in men and women in a dose-dependent fashion (total BMD p for trend <0.001 for men and 0.001 for women). Lumbar spine BMD was inversely associated with CRP in women but not in men and there was no association at the thoracic spine and pelvis BMD subregions. The associations were independent of prescriptions medications use, comorbidities, and other potential confounders. Sensitivity analyses with further adjustment for vitamin D levels confirmed the results (Figures).


Among men and women in a large representative population-based sample, hs-CRP is inversely and independently associated with BMD (total and some subregions) in a dose-dependent fashion.

To cite this abstract, please use the following information:
de Pablo, Paola, Buckley, Christopher; Association Between Bone Mineral Density and High-Sensitivity CRP in a Large Population-Based Sample [abstract]. Arthritis Rheum 2009;60 Suppl 10 :596
DOI: 10.1002/art.25676

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