Arthritis & Rheumatism, Volume 60,
October 2009 Abstract Supplement
The 2009 ACR/ARHP Annual Scientific Meeting
Philadelphia October 16-21, 2009.
Analysis of Factors Associated with Obesity in Psoriatic Arthritis
Anandarajah1, Allen P., Ritchlin2, Christopher T.
To examine the relationship between environmental factors and obesity in psoriatic arthritis (PsA) and rheumatoid arthritis (RA) and to determine factors associated with the outcome variable body mass index (BMI).
Patients were selected from the Consortium Of Rheumatology Researchers Of North America (CORRONA) database and matched for age, sex and disease duration. Univariate analysis was performed to determine if the matched PsA and RA cohorts differ in their association with several variables. These same covariates were examined in matched PsA and RA patients stratified by the categorical outcome variable BMI (<30 or >30) and logistic regression was then performed in the two cohorts using the same covariates.
Frequency matching (age, sex and disease duration) yielded 2389 RA and PsA pairs. Logistic regression revealed that the number of tender joints, non-smoking status, absence of exercise, depression, age, shorter disease duration and female gender were associated with an elevated BMI in PsA whereas only lack of exercise, non-smoking status and shorter disease duration were associated with obesity in the RA cohort. Stepwise logistic modeling revealed that after controlling for exercise, older age, shorter disease duration, depression and the presence of PsA were associated with an elevated BMI. Increased tender joint counts and female gender also increased the likelihood of obesity in the PsA but not the RA cohort.
These findings support a multiplicative model of obesity in PsA that results from interplay between the environment and factors related to the disease process that remain to be identified.
To cite this abstract, please use the following information:
Anandarajah, Allen P., Ritchlin, Christopher T.; Analysis of Factors Associated with Obesity in Psoriatic Arthritis [abstract]. Arthritis Rheum 2009;60 Suppl 10 :518