Arthritis & Rheumatism, Volume 60,
October 2009 Abstract Supplement
The 2009 ACR/ARHP Annual Scientific Meeting
Philadelphia October 16-21, 2009.
Associatioin of Primary and Secondary Sjgrens Syndrome in Lupus Families
Aggarwal1, Rachna, Scofield2, R. Hal
Systemic lupus erythematosus (SLE) and Sjögren's syndrome are closely related diseases, but the relationship of primary and secondary Sjögren's syndrome within families with SLE is not known. We undertook this study to determine whether primary Sjögren's syndrome is increased among SLE-unaffected, and whether primary and secondary Sjögren's syndrome are associated within families with SLE.
Families were collected through the Lupus Family Registry and Repository. All SLE patients met the 1982 revised classification criteria for SLE, and all families had at least one member with SLE.. All subjects completed a standardized questionnaire, and had autoantibodies determined by ELISA and double immunodiffusion. Sjögren's syndrome was considered present when subjects met the combined US-European Sjögren's classification criteria for dry mouth as well as dry eyes and had anti-Ro (or SSA).
Among a total of 2537 SLE patients, there were 505 (19.9%) SLE patients with secondary Sjögren's syndrome. There were 65 SLE-unaffected relatives of SLE patients who had primary Sjögren's syndrome, while none of 1304 age and sex matched healthy controls had Sjögren's (c2=12.7, p=0.02). Seventeen (26.2%) of the 65 subjects with primary Sjögren's had an SLE-affected relative with secondary Sjögren's syndrome, compared to 493 (7.1%) of 6922 SLE-unaffected family members without primary Sjögren's (c2=34.8, p<0.00001, odds ratio=5.0).
We find that primary Sjögren's is found among relatives of SLE patients statistically more often than in healthy controls. Furthermore, within these SLE families primary Sjögren's syndrome in SLE-unaffected members was associated with secondary Sjögren's. That is, there was a familial distribution of primary and secondary Sjögren's. Primary Sjögren's affected family members were about 5 times more likely to have an SLE-affected relative with secondary Sjögren's than family members without primary Sjögren's. These data suggest common susceptibility factors, possibly genetic, for primary and secondary Sjögren's syndrome.
To cite this abstract, please use the following information:
Aggarwal, Rachna, Scofield, R. Hal; Associatioin of Primary and Secondary Sjgrens Syndrome in Lupus Families [abstract]. Arthritis Rheum 2009;60 Suppl 10 :508