Arthritis & Rheumatism, Volume 60,
October 2009 Abstract Supplement
The 2009 ACR/ARHP Annual Scientific Meeting
Philadelphia October 16-21, 2009.
Relationship Between Synovial Blood Flow Signals and Angiogenesis Factors in Patients with Rheumatoid Arthritis by Power Doppler Ultrasonography
Hirai, Kenichiro, Kurosaka, Daitaro, Nishioka, Makiko, Miyamoto, Yukio, Yoshida, Ken, Kingetsu, Isamu, Fukuda, Kunihiko
To study the relationship between increases in the blood flow of the synovial blood vessels and vascularization observed in the synovial membrane of patients with rheumatoid arthritis by power Doppler ultrasonography (PDUS).
The subjects were 70 patients with RA who fulfilled the diagnostic criteria of the American College of Rheumatology. Ten joints: the bilateral wrists, elbows, shoulders, knees, and ankles, were examined by PDUS. The blood flow signals at synovial sites of each joint were scored 02, and the total blood flow scores of the 10 joints was calculated as the total signal score (TSS). The vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and interleukin-6 (IL-6) levels were determined by ELISA.
Significant correlations were observed between the TSS and serum VEGF, Ang-2, and IL-6 levels but not between the TSS and serum Ang-1 level.
The increases in the synovial blood flow signals in joints of RA patients observed by PDUS are likely to be caused by vascularization in synovial proliferation areas. They are particularly likely to represent the pathology in the period of marked vascularization, in which Ang-2 plays a dominant role.
To cite this abstract, please use the following information:
Hirai, Kenichiro, Kurosaka, Daitaro, Nishioka, Makiko, Miyamoto, Yukio, Yoshida, Ken, Kingetsu, Isamu, et al; Relationship Between Synovial Blood Flow Signals and Angiogenesis Factors in Patients with Rheumatoid Arthritis by Power Doppler Ultrasonography [abstract]. Arthritis Rheum 2009;60 Suppl 10 :375